Poster: Plant Pathogen/Symbiont Interactions
Abs #
698: Aminoethoxyvinylglycine and Propargylglycine: Inhibitors of conidial germination and mycelial growth of Fusarium oxysporum f. sp. luffae.
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Presenter: |
Lin, Chin-Ho , chlin@mail.nchu.edu.tw | Authors | Lin, Chin-Ho (A) Jin, Jung-Kang (A) Adams, Douglas O (B) Ko, Yeong (C) Yu, Chih-Wen (D) | | Affiliations: |
(A): Department of Life Science, National Chung Hsing University
(B): Department of Viticulture and Enology, University of California
(C): Department of Plant Pathology, National Chung Hsing University
(D): Department of Agricultural Biotechnology, Da-Yeh University
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Two inhibitors, aminoethoxyvinylglycine and propargylglycine, were tested for their ability to inhibit conidial germination and mycelial growth of Fusarium oxysporum f. sp. luffae. Aminoethoxyvinylglycine inhibited conidial germination in the range of 0.06-1.5 ppm. The linear inhibition range for mycelial growth was about 1.5-150 ppm. Although aminoethoxyvinylglycine did not completely inhibit both conidial germination and mycelial growth, it showed significant inhibitory effect at low concentration. The inhibition range for propargylglycine against conidial germination and mycelial growth were from 0.01 ppm to 1000 ppm and from 0.1 ppm to 100 ppm respectively. Propargylglycine completely inhibited conidial germination and mycelial growth at a concentration of 1000 ppm. The EC50 values of aminoethoxyvinylglycine were 0.2 ppm for conidial growth and 24 ppm for mycelial growth, and the EC50 values of propargylglycine were 5.4 ppm for conidial growth and 6.3 ppm for mycelial growth. Adding methionine can release inhibition of aminoethoxyvinylglycine or propargylglycine to conidial germination. In addition, a mixture of aminoethoxyvinylglycine and propargylglycine showed better inhibitive effect than applied solely. From these results, both aminoethoxyvinylglycine and propargylglycine were found to exhibit significant activity, and suggest that they can provide potential tools to design novel drugs against fungal pathogens.
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