Poster: Bioinformatics

Abs # 862: Identify the regulation of cold- and drought-responsive gene expression in Arabidopsis

Presenter:	Lee, Hsiao-Ching , d884234@oz.nthu.edu.tw
Authors	Lee, Hsiao-Ching  (A)   Li-Hsieh, Lin  (B)   Tsai-Yun, Lin  (A)
Affiliations:	(A): Institute of Bioinformatics and Structural Biology, National Tsing Hua University (B): Department of Electrical Engineering, National Tsing Hua University

Dehydration and low temperature turn on a set of genes containing C-repeat/dehydration-responsive elements in their promoter in plants. Previous studies have shown that the Arabidopsis CBF/DREB transcription activators are critical regulators of gene expression in the signal transduction of cold acclimation, but the regulatory pathway is not clear. It will be interesting to determine to what extent the pathway actives by the whole-genome microarrays. The mRNA expression profiles potentially reveal the information about the regulation cascade. Moreover, the promoter sequences characterize the interaction of transcription factors with the cis-elements. We conducted an extensive computational search for synergistic motifs by analyzing microarray expression data and provide a method that can identify the molecular mechanisms involved in transcriptional regulation and compare the signaling cascades in cold- and drought-stress using global and time serial gene expression-profiling techniques.