Symposium II: Reactive oxygen species: balancing signaling and stress
Abs #
20004: The Reactive Oxygen Gene Network of Plants
Reactive oxygen species (ROS) control many different processes in plants. However, they are also toxic molecules capable of injuring plant cells. How this conflict is resolved in cells is largely unknown. Nonetheless, it is clear that the steady-state level of ROS in cells needs to be tightly regulated. In Arabidopsis, a network of at least 152 genes is involved in regulating the level of ROS in cells. This network is highly dynamic and redundant, and encodes for ROS-scavenging as well as ROS-producing proteins. We are using a combination of Arabidopsis mutants, and molecular, biochemical and physiological tools to dissect the ROS gene network of Arabidopsis and determine its mode of regulation, its protective roles and its modulation of metabolic and signaling networks that control processes such as growth, hormonal signaling and biotic and abiotic stress response.
References:
Mittler, R. (2002) Ternds Plant Sci. 7, 405-410.
Pnueli, L., Hongjian, L. and Mittler, R. (2003) Plant J. 34, 187-203.
Rizhsky L, Liang H, Mittler R. (2003) J. Biol. Chem. 278, 38921-38925.
Rizhsky L., Davletova S., Liang H. and Mittler R. (2004). J. Biol. Chem. 279, 11736-11743
Supported by NSF grant 0343866
